Biscuit Pizza Casserole

Skip the takeout tonight and enjoy this comforting Biscuit Pizza Casserole that combines fluffy dough with gooey cheese and savory pepperoni. This easy-to-make dish requires only 10 minutes of preparation, making it the perfect solution for busy weeknights when you want a home-cooked meal without the stress.

Why You Will Love This Recipe

This Biscuit Pizza Casserole is a “bubble-up” style dish, meaning the refrigerated biscuit pieces rise and expand during baking to create a thick, pillowy crust that is infused with sauce and cheese. You will love how the Grands! Southern Homestyle Biscuits provide a tender, deep-dish texture that mimics your favorite thick-crust pizza. It is incredibly versatile, allowing you to swap toppings based on what you have in the pantry, and it bakes in one single pan for easy cleanup. Whether you are hosting a game day party or looking for a kid-friendly dinner, this recipe delivers maximum flavor with minimal effort.

Ingredients

• 16.3 oz can Grands! Southern Homestyle Biscuits (8 big biscuits)
• 14 oz jar pizza sauce
• 1 teaspoon Italian seasoning (divided)
• 2 1/2 cups shredded mozzarella cheese
• 5 oz pepperoni slices
• Pinch of red pepper flakes (optional)

Step-by-Step Instructions

1. Preheat your oven to 375°F and lightly grease a 9×13-inch baking dish with non-stick spray.
2. Open the can of biscuits and cut each of the 8 biscuits into 8 equal pieces to ensure even baking.
3. Spread the biscuit pieces evenly across the bottom of the prepared casserole dish.
4. Pour half of the jar of pizza sauce and sprinkle 1/2 teaspoon of Italian seasoning over the biscuits.
5. Stir the mixture gently to ensure every piece of biscuit is thoroughly coated with the sauce and seasoning.
6. Sprinkle approximately 1 cup of the mozzarella cheese over the biscuit mixture and stir again to distribute it evenly.
7. Pour the remaining pizza sauce over the top of the biscuit and cheese mixture.
8. Top the casserole with the remaining mozzarella cheese and the pepperoni slices (you can use mini pepperoni or cut regular slices in half).
9. Sprinkle the remaining 1/2 teaspoon of Italian seasoning and a pinch of red pepper flakes over the top for an extra kick of flavor.
10. Bake for 20 to 25 minutes, or until the biscuits have puffed up and the cheese is melted and golden brown.
11. Remove from the oven and let it sit for a few minutes before serving immediately.

Expert Tips / Pro Tips

To ensure the best results, always check the center of the casserole with a toothpick to make sure the biscuits are fully cooked through and not doughy. Cutting the biscuits into exactly 8 pieces each is vital for a consistent texture; if the pieces are too large, the outside may burn before the inside is finished. If you notice the cheese is browning too quickly, you can loosely tent the dish with aluminum foil for the last 5 minutes of baking. For an even richer flavor, consider brushing the tops of the exposed biscuits with a little melted garlic butter before serving.

This recipe is highly adaptable to your personal preferences. While Grands! Southern Homestyle Biscuits are recommended, you can use buttermilk or flaky layers biscuits as well. If you prefer different toppings, try adding cooked Italian sausage, diced green peppers, onions, mushrooms, or black olives. For a vegetarian version, simply omit the pepperoni and load up on extra veggies. You can also swap the mozzarella for a pizza blend or add a sprinkle of fresh Parmesan cheese for a sharper flavor profile.

Serving Suggestions

Biscuit Pizza Casserole is a hearty meal on its own, but it pairs beautifully with a fresh green salad or a homemade kale salad to balance the richness of the cheese. For a more vegetable-forward side, try a broccoli cauliflower salad. If you are serving this for a party or game night, you can cut it into smaller squares and serve it as a heavy appetizer alongside extra pizza sauce for dipping. It also goes great with a warm bowl of vegetable soup for a cozy winter dinner.

MAKE AHEAD: You can assemble the casserole up until the baking step, cover it tightly with plastic wrap, and store it in the refrigerator for a few hours before baking.

IN THE FRIDGE: Store any leftovers in an airtight container for 2 to 3 days.

IN THE FREEZER: This casserole can be frozen for up to two months. Wrap the dish tightly in plastic wrap and then aluminum foil. Thaw in the refrigerator overnight before reheating.

REHEATING: To maintain the texture, reheat leftovers in a 375°F oven until the cheese is bubbly. For a quick lunch, you can also use the microwave on medium power in 30-second intervals until heated through.

Nutrition Information

Biscuit Pizza Casserole

Skip the takeout and make this easy Biscuit Pizza Casserole tonight. This homemade dish marries the comfort of a hearty casserole with the simplicity of your favorite pizza toppings for a meal that takes just 10 minutes to prepare. It is a perfect solution for busy weeknights when you want the flavor of a deep-dish pizza without the wait.

Print Recipe Pin Recipe

Prep Time 10 minutes mins

Cook Time 25 minutes mins

Total Time 35 minutes mins

Servings: 8 servings

Course: Casserole, Dinner, Main Course

Cuisine: American, Italian

Calories: 370

Ingredients Equipment Method Notes

Ingredients

  

• 1 16.3 oz can Grands! Southern Homestyle Biscuits 8 big biscuits
• 1 14 oz jar pizza sauce
• 1 tsp Italian seasoning divided
• 2.5 cups shredded mozzarella cheese
• 5 oz pepperoni slices
• 1 pinch red pepper flakes optional

Equipment

• 9×13-inch casserole dish

Method

 

1. Preheat the Oven: Start by preheating your oven to 375°F. Grease a 9×13-inch casserole dish with non-stick spray or butter.
2. Prepare the Biscuits: Remove the biscuits from the can and cut each individual biscuit into 8 equal pieces. Ensuring they are cut evenly is key to a consistent texture and even baking.
   1 16.3 oz can Grands! Southern Homestyle Biscuits
3. Layer the Base: Spread the biscuit pieces evenly across the bottom of the prepared 9×13 casserole dish.
4. Sauce and Season: Pour half of the jar of pizza sauce and half a teaspoon of Italian seasoning over the biscuits. Stir the mixture gently to ensure all biscuit pieces are thoroughly coated with sauce.
   1 14 oz jar pizza sauce, 1 tsp Italian seasoning
5. Add Cheese: Sprinkle approximately 1 cup of the shredded mozzarella cheese over the biscuit mixture and stir again to distribute the cheese throughout the base.
   2.5 cups shredded mozzarella cheese
6. Top with Remaining Sauce: Pour the remaining pizza sauce evenly over the top of the biscuit and cheese mixture.
   1 14 oz jar pizza sauce
7. Layer Toppings: Top the casserole with the remaining mozzarella cheese. You can use as much as you like for an extra cheesy result. Layer the pepperoni slices across the top.
   2.5 cups shredded mozzarella cheese, 5 oz pepperoni slices
8. Final Seasoning: Sprinkle the remaining half teaspoon of Italian seasoning and the red pepper flakes (to your desired heat level) over the top of the casserole.
   1 tsp Italian seasoning, 1 pinch red pepper flakes
9. Bake: Place the dish in the oven and bake for 20 to 25 minutes. The casserole is ready when the biscuits have puffed up, and the cheese is melted and beginning to turn golden brown.
10. Serve: Remove from the oven and serve immediately. You can serve it with extra pizza sauce on the side for dipping if desired.

Notes

Use a toothpick to check the center biscuits for doneness; if it comes out clean, the dough is fully cooked. If the cheese browns too quickly before the biscuits are done, loosely tent the dish with aluminum foil.

FAQ